Dimethyl Sulfoxide
Apexbio Technology LLC GYY 4137 morpholine salt(Synonyms: GYY4137, Morpholin-4-ium 4-methoxyphenyl(morpholino)phosphinodithioate, GYY-4137), 10mM (in 1mL DMSO), CAS: 106740-09-4.
GYY 4137 morpholine salt (CAS 106740-09-4) is a slow-releasing hydrogen sulfide (H S) donor that exerts biological activity by modulating signaling pathways involved in vasodilation and blood pressure regulation In experimental studies this compound demonstrates the capacity to suppress cellular proliferation induce apoptosis and arrest cell cycle progression Due to these properties GYY 4137 morpholine salt is widely utilized in research investigating hypertension inflammation and cancer biology
Apexbio Technology LLC Phenacetin 62-44-2 10mM (in 1mL DMSO)
Phenacetin (CAS 62-44-2) is a synthetic non-opioid analgesic historically utilized for alleviating pain and reducing fever lacking intrinsic anti-inflammatory effects Its analgesic mechanism primarily involves inhibition of cyclooxygenase (COX) enzyme activity in the central nervous system leading to decreased prostaglandin synthesis Previously studied for its pharmacological action on pain modulation pathways phenacetin serves currently as an experimental reference compound in evaluating nephrotoxic effects in biomedical research following its market withdrawal due to nephropathy concerns
Apexbio Technology LLC PD 151746 179461-52-0 10mM (in 1mL DMSO)
PD 151746 is a cell-permeable inhibitor that selectively targets calpain a calcium-dependent cysteine protease involved in various cellular processes With a Ki value of 0 26 M against -calpain it prevents the proteolytic cleavage of substrates like neuronal nitric oxide synthase (nNOS) and calmodulin-dependent protein kinase II-alpha (CaMPK-II) particularly under stress In neuronal models PD 151746 inhibits apoptosis induced by serum/potassium withdrawal reduces MEF2 phosphorylation suppresses cdk5/p25 complex formation and decreases caspase-3 activation In HepG2 hepatoma cells it disrupts insulin-stimulated glycogen synthesis and affects protein tyrosine phosphatase-2 (PTP2) expression PD 151746 is used in research to study calpain-related signaling pathways apoptosis cell motility and metabolism
Apexbio Technology LLC Darifenacin HBr 133099-07-7 10mM (in 1mL DMSO)
Darifenacin HBr (CAS 133099-07-7) known as UK88525 is a selective antagonist of the M3 muscarinic acetylcholine receptor (mAChR M3) It demonstrates high binding affinity (pKi 8 9) toward M3 receptors which mediate smooth muscle contraction and glandular secretion in various tissues In vitro studies reveal that darifenacin acts as a substrate of the P-gp efflux transporter at the blood-brain and blood-ocular barriers In animal models darifenacin modulates bladder contractility and reduces bladder afferent nerve activity Clinically it is employed in research focusing on disorders involving abnormal detrusor muscle activity such as overactive bladder syndrome
Apexbio Technology LLC Entecavir Hydrate 209216-23-9 10mM (in 1mL DMSO)
Entecavir hydrate is an antiviral compound that acts as a reverse transcriptase (RT) inhibitor specifically targeting hepatitis B virus (HBV) infection It inhibits HBV DNA replication by interacting with the viral reverse transcriptase enzyme thus preventing the synthesis of complementary DNA from the viral RNA template Entecavir hydrate is frequently employed in antiviral studies and clinical research related to hepatitis B treatment regimens In studies involving chronic HBV-infected patients entecavir hydrate combined with peginterferon alpha-2b therapy has shown significant suppression of viral DNA levels and reduced covalently closed circular DNA (cccDNA) within hepatocytes The reported IC50 value of entecavir hydrate against HBV DNA polymerase activity typically ranges below 10 nM in cellular assay systems enabling its utility in both preclinical and clinical antiviral investigations
Medchemexpress LLC Dimethyl sulfoxide | 67-68-5 | MFCD00002089 | 100.0% | 78.13 g/mol | C2H6OS | 50mL
Dimethyl sulfoxide (DMSO) (GMP Like) is the GMP Like class Dimethyl sulfoxide (HY-Y0320C) Dimethyl sulfoxide is an aprotic solvent that can dissolve water-insoluble therapeutic and toxic agents Dimethyl sulfoxide has a strong affinity for water and has the ability to rapidly penetrate or enhance the penetration of other substances through biological membranes Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity[1]
Apexbio Technology LLC BI 2536(Synonyms: BI-2536, BI2536, Plk1 inhibitor BI 2536), 10mM (in 1mL DMSO), CAS: 755038-02-9.
BI 2536 (CAS number 755038-02-9) is an ATP-competitive inhibitor selectively targeting human polo-like kinase 1 (PLK1) exhibiting an IC50 value of approximately 0 83 nM Comparatively BI 2536 shows substantially less affinity towards other kinases In vitro studies demonstrate that BI 2536 inhibits proliferation of various human tumor cell lines (EC50 values ranging from 2 to 25 nM) and induces G2/M cell cycle arrest accompanied by apoptosis as evidenced in HeLa cervical cancer cells In vivo data from xenograft tumor models indicate that BI 2536 administered intravenously on a weekly or biweekly schedule possesses antitumor efficacy
Apexbio Technology LLC Olmesartan 144689-24-7 10mM (in 1mL DMSO)
Olmesartan (CAS 144689-24-7) is a small molecule angiotensin II receptor antagonist primarily acting by selectively blocking the binding of angiotensin II to AT1 receptors This mechanism interrupts angiotensin II-mediated vasoconstriction and aldosterone secretion resulting in antihypertensive effects In biomedical research Olmesartan serves as a valuable tool for examining hypertensive disease models elucidating angiotensin II signaling pathways and exploring therapeutic strategies targeting cardiovascular regulation
Apexbio Technology LLC Aloperine 56293-29-9 10mM (in 1mL DMSO)
Aloperine is a naturally derived alkaloid known for its biological properties including anti-inflammatory antiviral antibacterial and antitumor activities Mechanistic studies suggest that aloperine exerts anti-inflammatory effects through inhibition of inflammatory mediators and inflammatory signaling pathways such as nuclear factor-kappa B (NF- B) and mitogen-activated protein kinase (MAPK) pathways In vitro assays demonstrate antiviral potential related to inhibition of specific viral replication stages Additionally its antitumor properties have been identified in multiple cancer cell lines where aloperine can induce apoptosis inhibit proliferation and migration and modulate cell cycle progression Aloperine typically exhibits IC50 values ranging from low micromolar to sub-micromolar concentrations depending on cell lines and experimental settings It serves as a research tool compound in immunological oncological and infectious disease studies
Cayman Chemical L-MethIonIn SulfoxIde 25g
A sulfoxide-modified methionine; increases weight gain in weanling mice in the diet at 6.3, 12.6, and 18.9 mmol/g; levels are decreased in patients with vitiligo
Apexbio Technology LLC Embelin 550-24-3 10mM (in 1mL DMSO)
Embelin (CAS 550-24-3) is a natural benzoquinone derivative isolated from plants of the genus Embelia functioning as an inhibitor of X-linked inhibitor of apoptosis protein (XIAP) with an IC50 value of 4 1 M XIAP negatively regulates apoptosis by inhibiting caspase activation Embelin promotes apoptosis by interrupting XIAP-caspase interaction activating apoptotic pathways in tumor cells expressing elevated XIAP levels Additionally embelin can inhibit the NF- B signaling cascade through suppression of IKK activation thereby downregulating NF- B-mediated anti-apoptotic and metastatic gene expression In animal models embelin demonstrates anti-tumor properties by attenuating tumorigenesis related to inflammation-driven colorectal cancer through modulation of IL-6/STAT3 pathway signaling
Crescent Chemical Co Inc DIMETHYL SULFOXIDE
Dimethyl sulfoxide research grade Highly active solvent and pharmaceutical vehicle; for freezing cells. For gradient centrifugation (1). Determination of cysteine and cystine in proteins (2). Size - 1L Storage Conditions - +15 °C TO +30 °C Catalog Num
Apexbio Technology LLC Raltegravir (MK-0518) 518048-05-0 10mM (in 1mL DMSO)
Raltegravir (MK-0518) is an inhibitor targeting HIV-1 integrase an enzyme essential for viral genome integration into host cellular DNA This compound disrupts the integrase-catalyzed strand transfer step during viral replication thereby hindering productive HIV infection In vitro studies demonstrate that Raltegravir inhibits replication of multidrug-resistant strains and isolates utilizing either CCR5 or CXCR4 coreceptors Its reported IC50 values typically range within the low nanomolar concentration levels Raltegravir is widely employed as a tool molecule in antiviral mechanism research drug resistance assays and preclinical HIV therapy-focused drug screening studies
